LONG-TERM ADMINISTRATION OF L-ARGININE IMPROVES NITRIC-OXIDE RELEASE FROM KIDNEY IN DEOXYCORTICOSTERONE ACETATE SALT HYPERTENSIVE RATS

被引:58
作者
HAYAKAWA, H
HIRATA, Y
SUZUKI, E
KIMURA, K
KIKUCHI, K
NAGANO, T
HIROBE, M
OMATA, M
机构
[1] UNIV TOKYO,FAC MED,DEPT INTERNAL MED 2,BUNKYO KU,TOKYO 113,JAPAN
[2] UNIV TOKYO,FAC PHARMACEUT SCI,TOKYO 113,JAPAN
关键词
NITRIC OXIDE; ENDOTHELIUM; ARGININE; DEOXYCORTICOSTERONE; KIDNEY;
D O I
10.1161/01.HYP.23.6.752
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
To examine the effects of L-arginine (L-Arg) on endothelial function, we administered 0.5 g/L L-Arg in drinking water to deoxycorticosterone acetate (DOCA)-salt rats for 8 weeks and then measured nitric oxide (NO) release from isolated kidneys using a newly developed real-time chemiluminescence method. Renal pathology was also analyzed. Acetylcholine caused much smaller declines in renal perfusion pressure (10(-7) mol/L acetylcholine: -24 +/- 2% [SEM] versus -50 +/- 2%, P<.001) and NO release in DOCA-salt rats (+3 +/- 1 versus +33 +/- fmol/min per gram kidney weight, P<.001) compared with control rats. L-Arg did not influence the time course of systolic blood pressure elevation in DOCA-salt rats (211 +/- 5 versus 208 +/- 6 mm Hg, DOCA versus L-Arg/DOCA, P=NS). However, oral administration of L-Arg improved acetylcholine-induced declines in renal perfusion pressure (10(-7) mol/L acetylcholine: L-Arg/DOCA, -39 +/- 3%, P<.01 versus DOCA). This change was associated with an increase in NO release by acetylcholine (10(-7) mol/L acetylcholine: L-Arg/ DOCA, +10 +/- 1 fmol/min per gram kidney weight, P<.05 versus DOCA). However, morphological changes in renal vessels and glomeruli were similar between DOCA and L-Arg/DOCA rats. These results suggest that L-Arg administration partially reverses renal endothelial function with respect to vasorelaxation and NO release independent of blood pressure changes, indicating that hypertensive vessels seem to be depleted of L-Arg and/or have defects in the availability of L-Arg for NO synthesis.
引用
收藏
页码:752 / 756
页数:5
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