EXTRANEURONAL UPTAKE OF NORADRENALINE IN HUMAN TISSUE (UPTAKE(2))

被引：6

作者：

BABINEBELL, J

GLIESE, M

机构：

[1] Clinic of Cardiac and Thoracic Surgery, University of Würzburg, Würzburg, D-97080

[2] Clinic of Neurosurgery, University of Regensburg, Regensburg, 0-93053

来源：

HEART AND VESSELS | 1995年 / 10卷 / 03期

关键词：

UPTAKE(2); NORADRENALINE; HEART TISSUE;

D O I：

10.1007/BF01744482

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The neurotransmitter, noradrenaline, is inactivated by active transport out of the synaptic cleft, either back into the adrenergic neurons (uptake(1)) or into extraneuronal cells (uptake(2)). Although experimental models clearly demonstrate uptake(2) in various animal tissues, there are few reports of studies that demonstrate uptake(2) in human tissue. Furthermore, uptake(2) has never been described in human heart tissue. We demonstrated a reduction of H-3-noradrenaline uptake in human atrial and venous tissue and in rat atrial and Ventricular tissue by O-methylisoprenaline - a known inhibitor of uptake(2.) These results indicate that uptake(2), as has been described in previous experimental models, does exist in humans and further, the results emphasize the importance of uptake(2), since about 50% of exogenous noradrenaline is inactivated by uptake(2) in the rat heart.

引用

页码：151 / 153

页数：3

共 9 条

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