SEPARATION OF THE OPTICAL ISOMERS OF A NEW 1,4-DIHYDROPYRIDINE CALCIUM-CHANNEL BLOCKER (LF 2.0254) BY LIQUID AND SUPERCRITICAL-FLUID CHROMATOGRAPHY

被引：18

作者：

SIRET, L

MACAUDIERE, P

BARGMANNLEYDER, N

TAMBUTE, A

CAUDE, M

GOUGEON, E

机构：

[1] ECOLE SUPER PHYS & CHIM IND VILLE PARIS,CHIM ANALYT LAB,CNRS,UNITE RECH 437,10 RUE VAUQUELIN,F-75231 PARIS 05,FRANCE

[2] CTR ETUD BOUCHET,RECH & ETUD TECH,VERT LE PETIT,FRANCE

[3] SYNKEM,CHENOVE,FRANCE

来源：

CHIRALITY | 1994年 / 6卷 / 05期

关键词：

CALCIUM CHANNEL BLOCKER; DIASTEREOMERS; CHIRAL STATIONARY PHASES; LIQUID CHROMATOGRAPHY; SUPERCRITICAL FLUID CHROMATOGRAPHY;

D O I：

10.1002/chir.530060513

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The four optical isomers of a new calcium channel blocker LF 2.0254 (developed by Laboratoires Fournier) are resolved by chromatography using chiral stationary phases. Two methods are proposed: the first one involving two chiral stationary phases [(S)-N-(2-naphthyl)alanine, a Pirkle type CSP and Chiralcel OJ, a cellulose derived CSP] in the liquid chromatographic mode, the second one involving a single CSP (Chiralcel OJ) in the supercritical fluid chromatographic mode. (C) 1994 Wiley-Liss, Inc.

引用

页码：440 / 445

页数：6

共 20 条

[1]

Ariens EJ, 1989, CHIRAL SEPARATIONS H, P31

[2] SEPARATION OF METALLOCENE ENANTIOMERS BY LIQUID-CHROMATOGRAPHY - CHIRAL RECOGNITION VIA CYCLODEXTRIN BONDED PHASES [J].

ARMSTRONG, DW ;

DEMOND, W ;

CZECH, BP .

ANALYTICAL CHEMISTRY, 1985, 57 (02) :481-484

[3] SEPARATION OF DRUG STEREOISOMERS BY THE FORMATION OF BETA-CYCLODEXTRIN INCLUSION COMPLEXES [J].

ARMSTRONG, DW ;

WARD, TJ ;

ARMSTRONG, RD ;

BEESLEY, TE .

SCIENCE, 1986, 232 (4754) :1132-1135

[4]

BARGMANN N, 1992, ANALUSIS, V20, P189

[5]

BURSZTUM M, 1985, CLIN EXP HYPERT, V8, P1187

[6] DIRECT HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC RESOLUTION OF DIHYDROPYRIDINE ENANTIOMERS [J].

DELEE, E ;

JULLIEN, I ;

LEGARREC, L .

JOURNAL OF CHROMATOGRAPHY, 1988, 450 (02) :191-197

[7] ENANTIOSELECTIVE HANTZSCH DIHYDROPYRIDINE SYNTHESIS VIA METALATED CHIRAL ALKYL ACETOACETATE HYDRAZONES [J].

ENDERS, D ;

MULLER, S ;

DEMIR, AS .

TETRAHEDRON LETTERS, 1988, 29 (49) :6437-6440

[8]

GUAZZI MD, 1983, HYPERTENSION S2, V2, P5

[9] CHROMATOGRAPHIC-SEPARATION OF THE DIASTEREOMERS OF A DIHYDROPYRIDINE-TYPE CALCIUM-CHANNEL ANTAGONIST AS THE BIS-3,5-DINITROBENZOATES [J].

KERN, JR ;

LOKENSGARD, DM ;

YANG, TY .

JOURNAL OF CHROMATOGRAPHY, 1988, 457 :309-316

[10]

KUSTERS E, 1991, JHRC, V14, P769

← 1 2 →