THE UTILITY OF 2,5-DIDEOXY-2,5-IMINO-D-MANNITOL AS A PFP ENZYME-INHIBITOR

被引：14

作者：

CHORGHADE, MS

CSEKE, CT

LIU, PS

机构：

[1] DOW ELANCO,INDIANAPOLIS,IN 46268

[2] MARION MERRELL DOW RES CTR,CINCINNATI,OH 45215

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(00)86301-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

2,5-Dideoxy-2,5-imino-D-mannitol was synthesized from an arabinofuranose derivative. Mercuric acetate cyclization of an ene-carbamate was the key step. The compound proved to be an inhibitor of the pyrophosphate-fructose-6-phosphate-1-phosphotransferase (PFP) enzyme and has potential utility in the biorational design of herbicides.

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页码：2251 / 2254

页数：4

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