LOCUS-COERULEUS LESIONS POTENTIATE NEUROTOXIC EFFECTS OF MPTP IN DOPAMINERGIC-NEURONS OF THE SUBSTANTIA-NIGRA

被引：86

作者：

BING, GY

ZHANG, Y

WATANABE, Y

MCEWEN, BS

STONE, EA

机构：

[1] NYU,DEPT PSYCHIAT,NEW YORK,NY 10016

[2] ROCKEFELLER UNIV,MED CTR,NEW YORK,NY 10021

[3] ROCKEFELLER UNIV,NEUROENDOCRINOL LAB,NEW YORK,NY 10021

来源：

BRAIN RESEARCH | 1994年 / 668卷 / 1-2期

关键词：

MPTP; PARKINSONS DISEASE; DOPAMINE; NOREPINEPHRINE; LOCUS CERULEUS; SUBSTANTIA NIGRA;

D O I：

10.1016/0006-8993(94)90534-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The observation that Parkinson's disease (PD) is associated with locus coeruleus (LC) noradrenergic neuronal degeneration suggests that the LC noradrenergic system may be involved in the pathogenesis and natural progression of the destruction of the substantia nigra (SN) dopaminergic neurons in Parkinson's disease. The relationship of these two systems was examined by injection of subtoxic doses of MPTP into unilateral LC 6-hydroxydopamine (6-OHDA) lesioned mice. A significant loss of dopaminergic cells was only found in the SN on the side of the LC lesions. These results suggest that the LC may have protective effects on SN dopaminergic neurons.

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收藏

页码：261 / 265

页数：5

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