Genetic Instability of Influenza pH1N1 Viruses

被引：5

作者：

Jalovaara, Petri ^{[1
]}

Bychkov, Dmitrii ^{[1
]}

Ahtiainen, Laura ^{[1
]}

Kallio-Kokko, Hannimari ^{[2
]}

Valkonen, Miia ^{[3
]}

Kantele, Anu ^{[3
]}

Mattila, Pirkko ^{[1
]}

Almusa, Henrikki ^{[1
]}

Kallioniemi, Olli ^{[1
]}

Kainov, Denis ^{[1
]}

机构：

[1] FIMM, Helsinki, Finland

[2] Helsinki Univ Hosp Lab, HUSLAB, Helsinki, Finland

[3] Helsinki Univ Cent Hosp, HUCS, Helsinki, Finland

来源：

GENOME ANNOUNCEMENTS | 2014年 / 2卷 / 05期

基金：

芬兰科学院;

关键词：

D O I：

10.1128/genomeA.00841-14

中图分类号：

学科分类号：

摘要：

Here, we report full-length genome sequences of influenza pH1N1 viruses obtained prior to and after propagation in MDCK cells. Paired comparisons of the genomes showed that each strain acquired 1.0 to 18.8 mutations per genome per replication cycle, which corresponds to 0.5 to 5.8 mutations per virus proteome per replication cycle. Our analysis indicates that pH1N1 viruses accumulated adaptive mutations among others in response to propagation in cell culture. These results could be important for vaccine and drug-sensitivity surveillance studies, as well as for vaccine and antiviral drug development programs where cell cultures are used for influenza propagation.

引用

页数：1

共 4 条

[1]

Full-Genome Sequences of Influenza H3N2 Virus Strains Isolated from Finnish Patients during the 2012-2013 Epidemic Season [J].