PHARMACOKINETIC DETERMINANTS OF 6-MERCAPTOPURINE MYELOTOXICITY AND THERAPEUTIC FAILURE IN CHILDREN WITH ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：40

作者：

SULH, H

KOREN, G

WHALEN, C

SOLDIN, S

ZIPURSKY, A

GREENBERG, M

机构：

[1] HOSP SICK CHILDREN,RES INST,DIV CLIN PHARMACOL,555 UNIV AVE,TORONTO M5G 1X8,ONTARIO,CANADA

[2] HOSP SICK CHILDREN,RES INST,DIV HEMATOL ONCOL,TORONTO M5G 1X8,ONTARIO,CANADA

[3] HOSP SICK CHILDREN,DEPT PEDIAT,TORONTO M5G 1X8,ONTARIO,CANADA

[4] HOSP SICK CHILDREN,DEPT BIOCHEM,TORONTO M5G 1X8,ONTARIO,CANADA

[5] UNIV TORONTO,DEPT PEDIAT,TORONTO M5S 1A1,ONTARIO,CANADA

[6] UNIV TORONTO,DEPT PHARMACOL,TORONTO M5S 1A1,ONTARIO,CANADA

[7] UNIV TORONTO,DEPT CLIN BIOCHEM,TORONTO M5S 1A1,ONTARIO,CANADA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 1986年 / 40卷 / 06期

关键词：

D O I：

10.1038/clpt.1986.233

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：604 / 609

页数：6

共 18 条

[1] PHARMACOKINETIC PRINCIPLES OF ANTI-NEOPLASTIC DRUG-THERAPY [J].

ALLEN, LM .

JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 23 (2-3) :71-81

[2]

BALIS FM, 1983, CANCER RES, V43, P2342

[3]

BLEYER WA, 1985, PEDIATR CLIN N AM, V32, P557

[4]

CRAFT AW, 1981, CANCER TREAT REP, V65, P77

[5] METHOTREXATE CEREBROSPINAL-FLUID AND SERUM CONCENTRATIONS AFTER INTERMEDIATE-DOSE METHOTREXATE INFUSION [J].

EVANS, WE ;

HUTSON, PR ;

STEWART, CF ;

CAIRNES, DA ;

BOWMAN, WP ;

RIVERA, G ;

CROM, WR .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1983, 33 (03) :301-307

[6] 6-MERCAPTOPURINE - APPARENT LACK OF RELATION BETWEEN PRESCRIBED DOSE AND BIOLOGICAL EFFECT IN CHILDREN WITH LEUKEMIA [J].

HERBER, S ;

LENNARD, L ;

LILLEYMAN, JS ;

MADDOCKS, J .

BRITISH JOURNAL OF CANCER, 1982, 46 (01) :138-141

[7]

KEARNEY PJ, 1979, CANCER CHEMOTH PHARM, V3, P117

[8] GASTROINTESTINAL CLEARANCE OF DRUGS WITH ACTIVATED-CHARCOAL [J].

LEVY, G .

NEW ENGLAND JOURNAL OF MEDICINE, 1982, 307 (11) :676-678

[9]

METZLER CM, 1974, BIOMETRICS, V30, P562

[10]

MILLER DR, 1980, CANCER TREAT REP, V64, P381

← 1 2 →