HISTOLOGIC ASSESSMENT OF LYMPHOKINE-MEDIATED SUPPRESSION OF CHONDROCYTE GLYCOSAMINOGLYCAN SYNTHESIS

被引：19

作者：

TAPLITS, MS ^{[1
]}

CRISSMAN, JD ^{[1
]}

HERMAN, JH ^{[1
]}

机构：

[1] UNIV CINCINNATI,DEPT PATHOL,CINCINNATI,OH 45267

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 01期

关键词：

D O I：

10.1002/art.1780220110

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An experimental model has been developed to histologically assess the effect of T cell mitogen‐induced lymphokines derived from rabbit splenocytes on proteoglycan matrix depleted auricular cartilage explant glycosaminoglycan synthesis. Explant exposure to lymphokine was shown by light and electron microscopy to significantly suppress chondrocyte glycosaminoglycan regenerative capacity. This inhibitory effect was reversible in that synthetic activity could be restored by placement of explants in control media after as long as 12 days of lymphokine exposure. Copyright © 1979 American College of Rheumatology

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页码：66 / 70

页数：5

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