LORAZEPAM IN STATUS EPILEPTICUS

被引：65

作者：

WALKER, JE ^{[1
]}

HOMAN, RW ^{[1
]}

VASKO, MR ^{[1
]}

CRAWFORD, IL ^{[1
]}

BELL, RD ^{[1
]}

TASKER, WG ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT NEUROL,DALLAS,TX 75235

来源：

ANNALS OF NEUROLOGY | 1979年 / 6卷 / 03期

关键词：

D O I：

10.1002/ana.410060305

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Lorazepam, a dichloro‐3‐hydroxy‐1,4‐benzodiazepine, has been shown to be a potent anticonvulsant in animal models of epilsepsy and has minimal depressant effects on respiration and circulation in humans. The effects of this compound were studied in status epilepticus. Twenty‐five patients were given intravenous lorazepam during status epilepticus of varying cause. Four or 8 mg of the drug controlled status in 22 of the 25 patients. Although single seizures recurred in 5 of the 22 patients, none experienced recurrence of status during a prolonged follow‐up period. Transient respiratory arrest occurred in 1 patient, but no other significant complications were observed. Studies of plasma drug levels suggest that most patients attain good seizure control at concentrations between 30 and 100 ng per milliliter. Clinical observations indicate that repetitive injections are not required for continuing control of seizures in patients whose seizures are initially controlled. Lorazepam appears to be an effective and safe drug for treatment of status epilepticus, with a duration of control longer than that achieved with diazepam. Copyright © 1979 American Neurological Association

引用

页码：207 / 213

页数：7

共 15 条

[1] DANGERS OF TREATMENT OF STATUS EPILEPTICUS WITH DIAZEPAM [J].