CLOMIPHENE CITRATE THERAPY FOR MALE-INFERTILITY

被引:8
作者
ALLAG, IS
ALEXANDER, NJ
机构
[1] OREGON REG PRIMATE RES CTR,DEPT REPRODUCT PHYSIOL,505 NW 185TH AVE,BEAVERTON,OR 97005
[2] UNIV OREGON,HLTH SCI CTR,DEPT OBSTET GYNECOL,PORTLAND,OR 97201
[3] UNIV OREGON,HLTH SCI CTR,DEPT UROL,PORTLAND,OR 97201
[4] UNIV OREGON,HLTH SCI CTR,DEPT ANAT,PORTLAND,OR 97201
基金
美国国家卫生研究院;
关键词
D O I
10.1016/0090-4295(79)90184-5
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
We have summarized 697 reported cases of the use of clomiphene citrate for the improvement of semen quality. Basal levels of gonadotropins are useful criteria for the differential diagnosis of hypo- and hypergonadotropic hypogonadism. Patients with an intact hypothalamic-pituitary-gonadal axis are most likely to respond to clomiphene citrate. Twenty-five mg. per day, administered in a cyclic fashion for a period of six to nine months, caused the greatest improvement. A higher dose (50 mg. per day) may be effective in men who do not respond to 25 mg. During the course of therapy gonadotropin levels and semen samples should be analyzed periodically. This drug is not currently approved for use in men; the incidence of side effects, particularly with long-term treatment, is unknown. © 1979.
引用
收藏
页码:500 / 503
页数:4
相关论文
共 28 条
  • [1] ANDERSON DC, 1970, J ENDOCRINOL, V48, pR40
  • [2] CISCLOMIPHENE CITRATE IN MANAGEMENT OF OLIGOSPERMIA
    ANSARI, AH
    WIELAND, RG
    KLEIN, DE
    [J]. JOURNAL OF UROLOGY, 1972, 108 (01) : 131 - &
  • [3] BROWN JS, 1977, FERTIL STERIL, V28, P505
  • [4] CHECK JH, 1978, FERTIL STERIL, V30, P713
  • [5] CHECK JH, 1977, FERTIL STERIL, V28, P746
  • [6] EFFECT OF CLOMIPHENE ON URINARY GONADOTROPINS IN INFERTILE MEN
    CHRISTIANSEN, P
    [J]. ACTA ENDOCRINOLOGICA, 1972, 70 (04): : 654 - +
  • [7] COHEN BM, 1977, FERTIL STERIL, V28, P386
  • [8] CZERNIAK P, 1970, FERTIL STERIL, V21, P830
  • [9] EPSTEIN JA, 1977, FERTIL STERIL, V28, P741
  • [10] FOSS GL, 1973, J REPROD FERTIL, V32, P167