ISOLATION OF [PRO2,MET13]SOMATOSTATIN-14 AND SOMATOSTATIN-14 FROM THE FROG BRAIN REVEALS THE EXISTENCE OF A SOMATOSTATIN GENE FAMILY IN A TETRAPOD

被引：65

作者：

VAUDRY, H ^{[1
]}

CHARTREL, N ^{[1
]}

CONLON, JM ^{[1
]}

机构：

[1] CREIGHTON UNIV,SCH MED,DEPT BIOMED SCI,CTR REGULAT PEPTIDE,OMAHA,NE 68178

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 188卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)92409-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two somatostatin-related peptides were isolated in pure form from an extract of the brain of the European green frog, Rana ridibunda. The primary structure of the most abundant component was identical to that of mammalian somatostatin-14. The primary structure of the second component, present in approximately 5% of the abundance of somatostatin-14, was established as Ala-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Met-Cys. This sequence shows two substitutions (Pro for Gly2 and Met for Ser13) compared with mammalian somatostatin-14. The data provide evidence for a somatostatin gene family in tetrapods as well as in teleost fish. © 1992.

引用

页码：477 / 482

页数：6

共 19 条

[1]

ANDREWS PC, 1988, J BIOL CHEM, V263, P15809

[2] RAPID ANALYSIS OF AMINO-ACIDS USING PRE-COLUMN DERIVATIZATION [J].

BIDLINGMEYER, BA ;

COHEN, SA ;

TARVIN, TL .

JOURNAL OF CHROMATOGRAPHY, 1984, 336 (01) :93-104

[3] HYPOTHALAMIC POLYPEPTIDE THAT INHIBITS SECRETION OF IMMUNOREACTIVE PITUITARY GROWTH-HORMONE [J].

BRAZEAU, P ;

VALE, W ;

BURGUS, R ;

LING, N ;

BUTCHER, M ;

RIVIER, J ;

GUILLEMIN, R .

SCIENCE, 1973, 179 (4068) :77-79

[4]

BUNEL DT, 1992, IN PRESS MOL BRAIN R

[5] CHARACTERIZATION OF MELANOTROPIN-RELEASE-INHIBITING FACTOR (MELANOSTATIN) FROM FROG BRAIN - HOMOLOGY WITH HUMAN NEUROPEPTIDE-Y [J].

CHARTREL, N ;

CONLON, JM ;

DANGER, JM ;

FOURNIER, A ;

TONON, MC ;

VAUDRY, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3862-3866

[6] [SER5]-SOMATOSTATIN-14 - ISOLATION FROM THE PANCREAS OF A HOLOCEPHALAN FISH, THE PACIFIC RATFISH (HYDROLAGUS-COLLIEI) [J].

CONLON, JM .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1990, 80 (02) :314-320

[7] PRIMARY STRUCTURES OF SOMATOSTATINS FROM THE ISLET ORGAN OF THE HAGFISH SUGGEST AN ANOMALOUS PATHWAY OF POSTTRANSLATIONAL PROCESSING OF PROSOMATOSTATIN-1 [J].

CONLON, JM ;

ASKENSTEN, U ;

FALKMER, S ;

THIM, L .

ENDOCRINOLOGY, 1988, 122 (05) :1855-1859

[8] SOMATOSTATIN-RELATED AND GLUCAGON-RELATED PEPTIDES WITH UNUSUAL STRUCTURAL FEATURES FROM THE EUROPEAN EEL (ANGUILLA-ANGUILLA) [J].

CONLON, JM ;

DEACON, CF ;

HAZON, N ;

HENDERSON, IW ;

THIM, L .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1988, 72 (02) :181-189

[9] ISOLATION AND STRUCTURAL CHARACTERIZATION OF INSULIN, GLUCAGON AND SOMATOSTATIN FROM THE TURTLE, PSEUDEMYS-SCRIPTA [J].

CONLON, JM ;

HICKS, JW .

PEPTIDES, 1990, 11 (03) :461-466

[10]

CONLON JM, 1986, GEN COMP ENDOCR, V60, P406

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