THE CHEMICAL SYNTHESIS OF LARGE RANDOM PEPTIDE LIBRARIES AND THEIR USE FOR THE DISCOVERY OF LIGANDS FOR MACROMOLECULAR ACCEPTORS

被引：66

作者：

LAM, KS

HRUBY, VJ

LEBL, M

KNAPP, RJ

KAZMIERSKI, WM

HERSH, EM

SALMON, SE

机构：

[1] UNIV ARIZONA,DEPT CHEM,TUCSON,AZ 85721

[2] UNIV ARIZONA,ARIZONA CANC CTR,TUCSON,AZ 85721

[3] SELECTIDE CORP,TUCSON,AZ 85737

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(01)80224-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A method is outlined for preparing large, diverse peptide libraries (10(5)-10(7) peptides) such that there is one peptide per bead. These libraries can be used to screen for binding to macromolecular receptor (acceptor) molecules and to determine the structure of the peptides that bind.

引用

收藏

页码：419 / 424

页数：6

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