ELUCIDATION OF STRUCTURAL ABNORMALITIES OF THE X-CHROMOSOME USING FLUORESCENCE IN-SITU HYBRIDIZATION WITH A Y-CHROMOSOME PAINTING PROBE

被引：2

作者：

HOWELL, RT

MILLENER, R

THORNE, S

OLOUGHLIN, J

BRASSEY, J

MCDERMOTT, A

机构：

[1] S. W. Regional Cytogenetics Centre, Southmead Hospital

来源：

JOURNAL OF MEDICAL GENETICS | 1994年 / 31卷 / 03期

关键词：

D O I：

10.1136/jmg.31.3.206

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Particular regions of the X and Y chromosomes share DNA sequence homology to the extent that cross hybridisation occurs. Thus, chromosome painting with a whole Y chromosome probe consistently results in fluorescence on specific regions of the X chromosome as well as the complete Y chromosome. This phenomenon has been exploited to elucidate the structure of unusual X chromosome rearrangements, without Y involvement, in two females.

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页码：206 / 208

页数：3

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