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ACTIVE MICROGLIA, SICK ASTROGLIA AND ALZHEIMER-TYPE DEMENTIAS

被引：36
作者：
NIETOSAMPEDRO, M [1 ]
MORA, F [1 ]
机构：
[1] UNIV MADRID, SCH MED, DEPT PHYSIOL, MADRID, SPAIN
来源：
NEUROREPORT | 1994年 / 5卷 / 04期
关键词：
MICROGLIA; ASTROGLIA; ALZHEIMERS DISEASE; AMYLOID; CALCIUM; TAU PROTEIN; APOLIPOPROTEIN E; AXONAL TRANSPORT; NEURODEGENERATION; GLUTAMATE; IL-1;
D O I：
10.1097/00001756-199401120-00001
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We propose that Alzheimer's disease is initiated by failure of axonal transport. After the neurodegeneration cascade is initiated, microglial and astroglial cells have major roles in directly and indirectly promoting self-sustaining neurodegeneration cycles. This hypothesis makes testable predictions and suggests logical therapies.
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收藏
页码：375 / 380
页数：6
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