PHYSIOLOGICAL CONTROL OF METABOLIC FLUX - THE REQUIREMENT FOR MULTISITE MODULATION

被引：187

作者：

FELL, DA

THOMAS, S

机构：

[1] School of Biological Sciences, Oxford Brookes University, Headington

来源：

BIOCHEMICAL JOURNAL | 1995年 / 311卷

关键词：

D O I：

10.1042/bj3110035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biochemists have long assumed that the flux through a metabolic pathway can be controlled by the activity of a key regulatory enzyme near the beginning of the pathway. We present the accumulating evidence that every step in this assumption is flawed. Instead, effective physiological control of metabolism is shown to involve simultaneous multisite modulation through action on a number of enzymes.

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页码：35 / 39

页数：5

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