DOSE-RESPONSE FOR BLOOD-PRESSURE AND DEGREE OF CARDIAC BETA-BLOCKADE WITH ATENOLOL

被引：13

作者：

MARSHALL, AJ ^{[1
]}

HEATON, S ^{[1
]}

BARRITT, DW ^{[1
]}

HARRY, JD ^{[1
]}

机构：

[1] ICI LTD,DEPT CLIN RES,DIV PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

POSTGRADUATE MEDICAL JOURNAL | 1979年 / 55卷 / 646期

关键词：

D O I：

10.1136/pgmj.55.646.537

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The hypotensive effect of 25 mg, 50 mg, 75 mg, 100 mg and 0 mg of atenolol daily were compared in a double-blind within-patient study. The fall in blood pressure with 25 mg daily was not significantly different than with 100 mg. The dose response curve lies between 0 and 25 mg daily. Cardiac, β-blockade (measured by suppression of exercise tachycardia) was not maximal with 25 mg of atenolol daily. The dose response curves for, β-blockade and the hypotensive effect are not parallel. © 1979 The Fellowship of Postgraduate Medicine.

引用

页码：537 / 540

页数：4