PITUITARY METABOLISM OF 5-ALPHA-ANDROSTANE-3-BETA-17-BETA-DIOL - INTENSE AND RAPID CONVERSION INTO 5-ALPHA-ANDROSTANE-3-BETA,6-ALPHA,17-BETA-TRIOL AND 5-ALPHA-ANDROSTANE-3-BETA,7-ALPHA,17-BETA-TRIOL

被引：31

作者：

GUIRAUD, JM ^{[1
]}

MORFIN, R ^{[1
]}

DUCOURET, B ^{[1
]}

SAMPEREZ, S ^{[1
]}

JOUAN, P ^{[1
]}

机构：

[1] FAC SCI & TECH BREST,BIOCHIM LAB,CNRS,EQUIPE RECH 784,F-29283 BREST,FRANCE

来源：

STEROIDS | 1979年 / 34卷 / 03期

关键词：

D O I：

10.1016/0039-128X(79)90076-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the male rat pituitary, 5α-androstane-3β,17β-diol (3β-diol) is extensively metabolized into polar steroids. They were identified as 5α-androstane-3β,6α-17β-triol (6α-triol) and 5α-androstane-3β,7α,17β-triol (7α-triol). 6α-Triol represents 53 % and 7α-Triol 28 % of the total 3β-diol metabolites. The remaining percentage is related to 6β and 7β isomers. The biological role of triols is still unknown. © 1979.

引用

页码：241 / 248

页数：8

共 25 条

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