GENETIC-HETEROGENEITY OF HYPERPEPSINOGENEMIC-I AND NORMOPEPSINOGENEMIC-I DUODENAL-ULCER DISEASE

被引:63
作者
ROTTER, JI
PETERSEN, G
SAMLOFF, IM
MCCONNELL, RB
ELLIS, A
SPENCE, MA
RIMOIN, DL
机构
[1] UNIV LIVERPOOL, LIVERPOOL L69 3BX, MERSEYSIDE, ENGLAND
[2] UNIV CALIF LOS ANGELES, HARBOR GEN HOSP, MED CTR, DIV GASTROENTEROL, TORRANCE, CA 90509 USA
[3] UNIV CALIF LOS ANGELES, SCH MED, DEPT PSYCHIAT, LOS ANGELES, CA 90024 USA
[4] UNIV CALIF LOS ANGELES, SCH MED, DEPT BIOMATH, LOS ANGELES, CA 90024 USA
[5] BROADGREEN HOSP, LIVERPOOL, ENGLAND
关键词
D O I
10.7326/0003-4819-91-3-372
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In a search for a genetic marker of duodenal ulcer, we measured serum pepsinogen I levels in 168 ulcer patients and 151 of their clinically normal siblings. The ulcer patients tended to have either hyperpepsinogenemia I (pepsinogen I, ≥ 100 ng/mL) or a normal level on a familial basis. Further evidence supporting this separation was the finding that the mean serum pepsinogen I level in the clinically normal siblings of the hyperpepsinogenemic patients was 91.2 ng/mL, significantly higher than the mean level (63.1 ng/mL) in the normal siblings of the normopepsinogenemic I patients. In the hyperpepsinogenemic I families the results of segregation analysis of an elevated pepsinogen I were consistent with autosomal-dominant inheritance of this trait. The genetic basis of normopepsinogenemic I duodenal ulcer was also shown by the familial aggregation of this disorder. These data provide direct evidence for genetic heterogeneity of duodenal ulcer disease.
引用
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页码:372 / 377
页数:6
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