PLASMA-LIPID LOWERING EFFECTS OF WHEAT-GERM IN HYPERCHOLESTEROLEMIC SUBJECTS

被引：18

作者：

CARA, L ^{[1
]}

BOREL, P ^{[1
]}

ARMAND, M ^{[1
]}

SENFT, M ^{[1
]}

LAFONT, H ^{[1
]}

PORTUGAL, H ^{[1
]}

PAULI, AM ^{[1
]}

BOULZE, D ^{[1
]}

LACOMBE, C ^{[1
]}

LAIRON, D ^{[1
]}

机构：

[1] INSERM,U130,18 AVE MOZART,F-13009 MARSEILLE,FRANCE

来源：

PLANT FOODS FOR HUMAN NUTRITION | 1991年 / 41卷 / 02期

关键词：

HUMAN; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; SERUM LIPOPROTEINS; WHEAT GERM;

D O I：

10.1007/BF02194082

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The present study was performed to investigate the possible effects of wheat germ supplementation on lipid metabolism in humans. Ten free-living adult subjects participated in the study. None was obese or diabetic. They all presented an hypercholesterolemia (from 6.58 to 9.50 mM), associated in 6 over 10 cases to an hypertriglyceridemia (from 1.70 to 5.0 mM). The subjects were studied in three consecutive periods, during which they first were on their usual diet (first week), they then ingested a daily supplement of 30 g wheat germ (4 weeks) and then they returned to their usual basal diet (4 weeks follow-up). Dietary records were obtained for 7 and 3 consecutive days before and during wheat germ supplementation, respectively. Fasting blood samples were taken at the end of each period. After 4 weeks of wheat germ intake, glycemia did not change while total plasma cholesterol significantly decreased (paired Student's t test, p less-than-or-equal-to 0.05) from 7.80 to 7.15 mM. LDL and HDL cholesterol values did not show marked changes, but VLDL cholesterol significantly dropped by 40.6%. Thus, the plasma/HDL total cholesterol ratio was significantly lower. Apoprotein B and Al decreased. In the hypertriglyceridemic subjects, this was accompanied by a significant reduction of plasma triglycerides (1.64 vs. 2.68 mM) and a marked drop of VLDL triglycerides (-51%). Taken as a whole, the present results obtained in humans are very close to those previously obtained in the rat [40] and point out that wheat germ may play a beneficial role in the dietary management of hyperlipidemia.

引用

页码：135 / 150

页数：16

共 62 条

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