SIMPLE SYNTHESIS OF L-GAMMA-CARBOXYGLUTAMATE AND DERIVATIVES THEREOF

被引：57

作者：

DANISHEFSKY, S

BERMAN, E

CLIZBE, LA

HIRAMA, M

机构：

[1] Department of Chemistry, University of Pittsburgh, Pittsburgh

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1979年 / 101卷 / 15期

关键词：

D O I：

10.1021/ja00509a062

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The curious amino acid, L-γ-carboxyglutamate (Gla), has been encountered in several of the vitamin K dependent blood clotting factors, including prothrombin.1 Activation of prothrombin to thrombin apparently involves preliminary calcium ion mediated binding of the former to membrane phospholipids, 2 thereby increasing the effective concentrations of the necessary factors. Gla units, which comprise 10 of the first 38 amino acid residues in prothrombin, are thought to be implicated in the calcium binding sites of prothrombin. © 1979, American Chemical Society. All rights reserved.

引用

页码：4385 / 4386

页数：2

共 23 条

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