SUSTAINED FETAL PULMONARY VASODILATION WITH PROLONGED ATRIAL-NATRIURETIC-FACTOR AND GMP INFUSIONS

被引:41
作者
ABMAN, SH
ACCURSO, FJ
机构
[1] UNIV COLORADO,SCH MED,PEDIAT PULM & CRIT CARE MED SECT,DENVER,CO 80262
[2] UNIV COLORADO,SCH MED,DEPT PEDIAT,DIV PERINATAL RES,DENVER,CO 80262
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1991年 / 260卷 / 01期
关键词
GUANOSINE; 3'; 5'-CYCLIC MONOPHOSPHATE; DESENSITIZATION; ENDOTHELIUM-DERIVED RELAXING FACTOR; FETUS; MYOGENIC RESPONSE; NEONATAL PULMONARY HYPERTENSION; POSTNATAL ADAPTATION; PROSTAGLANDINS; PULMONARY CIRCULATION; PULMONARY HYPERTENSION; TACHYPHYLAXIS;
D O I
10.1152/ajpheart.1991.260.1.H183
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
To study mechanisms of vasodilation and factors that maintain high pulmonary vascular resistance in utero, we measured changes in blood flow and the pressure-flow relationship of the pulmonary circulation during prolonged exposures to direct-acting guanosine 3',5'-cyclic monophosphate (cGMP) vasodilators, atrial natriuretic factor (ANF), and 8-bromoguanosine 3',5'-cyclic monophosphate (8-BrcGMP) and compared hemodynamic responses with other vasodilator stimuli in chronically prepared fetal lambs. The fetus was treated with 2 h of intrapulmonary infusions of ANF (0.15-mu-g/min), 8-BrcGMP (50-mu-g/min), prostaglandin D2 (PGD2, 0.4-mu-g/min), or acetylcholine (ACh, 1.5-mu-g/min) or increases in fetal PO2. Despite continued exposure to increased PO2, PGD2, and ACh, elevations of pulmonary blood flow and slopes of the pressure-flow relationship were not sustained, with both significantly decreased at 2 h from peak values. In contrast, pulmonary blood flow and pressure-flow slopes remained increased throughout 2 h of exposures to ANF and 8-BrcGMP. Adenosine 3',5'-cyclic monophosphate caused less change in blood flow than 8-BrcGMP within the dose range studied. We conclude that unlike other stimuli, direct-acting cGMP vasodilators are able to sustain vascular relaxation of the fetal pulmonary circulation.
引用
收藏
页码:H183 / H192
页数:10
相关论文
共 44 条
[1]  
ABMAN SH, 1990, PEDIATR RES, V27, pA351
[2]   ADAPTATION OF FETAL PULMONARY BLOOD-FLOW TO LOCAL INFUSION OF TOLAZOLINE [J].
ABMAN, SH ;
WILKENING, RB ;
WARD, RM ;
ACCURSO, FJ .
PEDIATRIC RESEARCH, 1986, 20 (11) :1131-1135
[3]   ACUTE EFFECTS OF PARTIAL COMPRESSION OF DUCTUS-ARTERIOSUS ON FETAL PULMONARY CIRCULATION [J].
ABMAN, SH ;
ACCURSO, FJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (02) :H626-H634
[4]   TIME-DEPENDENT RESPONSE OF FETAL PULMONARY BLOOD-FLOW TO AN INCREASE IN FETAL OXYGEN-TENSION [J].
ACCURSO, FJ ;
ALPERT, B ;
WILKENING, RB ;
PETERSEN, RG ;
MESCHIA, G .
RESPIRATION PHYSIOLOGY, 1986, 63 (01) :43-52
[5]  
ACCURSO FJ, 1988, P SOC EXP BIOL MED, V187, P89
[6]   CENTRAL SHUNT FLOWS AND PRESSURES IN THE MATURE FETAL LAMB [J].
ANDERSON, DF ;
BISSONNETTE, JM ;
FABER, JJ ;
THORNBURG, KL .
AMERICAN JOURNAL OF PHYSIOLOGY, 1981, 241 (01) :H60-H66
[7]   EFFECTS OF HYPERBARIC OXYGEN ON UTEROPLACENTAL AND FETAL CIRCULATION [J].
ASSALI, NS ;
KIRSCHBAUM, TH ;
DILTS, PV .
CIRCULATION RESEARCH, 1968, 22 (05) :573-+
[8]   REGULATION OF ADENYLYL CYCLASE-COUPLED BETA-ADRENERGIC RECEPTORS [J].
BENOVIC, JL ;
BOUVIER, M ;
CARON, MG ;
LEFKOWITZ, RJ .
ANNUAL REVIEW OF CELL BIOLOGY, 1988, 4 :405-428
[9]   H2O2 AND CGMP MAY FUNCTION AS AN O-2 SENSOR IN THE PULMONARY-ARTERY [J].
BURKEWOLIN, T ;
WOLIN, MS .
JOURNAL OF APPLIED PHYSIOLOGY, 1989, 66 (01) :167-170
[10]  
CASSIN S, 1975, P SOC EXP BIOL MED, V148, P584