FLURBIPROFEN (ANSAID) CROSS-SENSITIVITY IN AN ASPIRIN-SENSITIVE ASTHMATIC PATIENT

被引：15

作者：

BOSSO, JV ^{[1
]}

CREIGHTON, D ^{[1
]}

STEVENSON, DD ^{[1
]}

机构：

[1] SCRIPPS RES INST, DEPT MOLEC & EXPTL MED, DIV ALLERGY & IMMUNOL, LA JOLLA, CA 92037 USA

来源：

CHEST | 1992年 / 101卷 / 03期

关键词：

D O I：

10.1378/chest.101.3.856

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Flurbiprofen (Ansaid) is a newly released nonsteroidal anti-inflammatory drug (NSAID) that is a potent inhibitor of prostaglandin synthesis. We report the first case (to our knowledge) of a flurbiprofen-induced asthmatic reaction confirmed by single-blind oral challenges. Cross-sensitivity and cross-desensitization between aspirin (ASA) and flurbiprofen were also demonstrated in this patient with rhinosinusitis and asthma, thus reinforcing the observation that NSAIDs capable of cyclooxygenase inhibition cross-react with ASA in producing characteristic respiratory reactions.

引用

页码：856 / 858

页数：3

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