LOCALIZATION OF THE NUCLEOTIDE EXCISION REPAIR GENE ERCC6 TO HUMAN-CHROMOSOME 10Q11-Q21

被引：32

作者：

TROELSTRA, C

LANDSVATER, RM

WIEGANT, J

VANDERPLOEG, M

VIEL, G

BUYS, CHCM

HOEIJMAKERS, JHJ

机构：

[1] ERASMUS UNIV, CTR MED GENET, DEPT CELL BIOL & GENET, POB 1738, 3000 DR ROTTERDAM, NETHERLANDS

[2] UNIV GRONINGEN, DEPT MED GENET, 9700 AB GRONINGEN, NETHERLANDS

[3] SYLVIUS LAB, DEPT CYTOCHEM & CYTOMETRY, LEIDEN, NETHERLANDS

来源：

GENOMICS | 1992年 / 12卷 / 04期

关键词：

D O I：

10.1016/0888-7543(92)90304-B

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster ovary cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse × human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis. © 1992.

引用

页码：745 / 749

页数：5

共 29 条

[1] SUMMARY OF COMPLEMENTATION GROUPS OF UV-SENSITIVE CHO-CELL MUTANTS ISOLATED BY LARGE-SCALE SCREENING
BUSCH, D
GREINER, C
LEWIS, K
FORD, R
ADAIR, G
THOMPSON, L
[J]. MUTAGENESIS, 1989, 4 (05) : 349 - 354
[2] CALLEN DF, 1986, ANN GENET-PARIS, V29, P235
[3] Cleaver J. E., 1989, METABOLIC BASIS INHE, V2, P2949
[4] COLLINS A, 1987, J CELL SCI, P61
[5] GENETIC HETEROGENEITY OF XERODERMA PIGMENTOSUM DEMONSTRATED BY SOMATIC CELL HYBRIDIZATION
DEWEERDK.EA
BOOTSMA, D
KEIJZER, W
[J]. NATURE-NEW BIOLOGY, 1972, 238 (81): : 80 - &
[6] Friedberg E. C., 1985, DNA REPAIR
[7] HUMAN CHROMOSOME-9 CAN COMPLEMENT UV SENSITIVITY OF XERODERMA-PIGMENTOSUM GROUP-A CELLS
ISHIZAKI, K
OSHIMURA, M
SASAKI, MS
NAKAMURA, Y
IKENAGA, M
[J]. MUTATION RESEARCH, 1990, 235 (03): : 209 - 215
[8] JAMES CD, 1988, CANCER RES, V48, P5546
[9] COMPLEMENTATION OF A DNA-REPAIR DEFECT IN XERODERMA PIGMENTOSUM-CELLS BY TRANSFER OF HUMAN CHROMOSOME-9
KAUR, GP
ATHWAL, RS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) : 8872 - 8876
[10] FAMILIAL MEDULLARY-THYROID CARCINOMA AND MULTIPLE ENDOCRINE NEOPLASIA TYPE-2B MAP TO THE SAME REGION OF CHROMOSOME-10 AS MULTIPLE ENDOCRINE NEOPLASIA TYPE-2A
LAIRMORE, TC
HOWE, JR
KORTE, JA
DILLEY, WG
AINE, L
AINE, E
WELLS, SA
DONISKELLER, H
[J]. GENOMICS, 1991, 9 (01) : 181 - 192

← 1 2 3 →