STRUCTURE-ACTIVITY-RELATIONSHIPS FOR UNSATURATED DIALDEHYDES .6. THE MUTAGENIC ACTIVITY OF 11 COMPOUNDS IN THE V79/HGPRT ASSAY

被引：18

作者：

MORALES, P

ANDERSSON, M

LEWAN, L

STERNER, O

机构：

[1] LUND INST TECHNOL,DEPT ORGAN CHEM 2,POB 124,S-22100 LUND,SWEDEN

[2] UNIV LUND,DEPT ZOOPHYSIOL,S-22101 LUND,SWEDEN

来源：

MUTATION RESEARCH | 1992年 / 268卷 / 02期

关键词：

SESQUITERPENES; UNSATURATED DIALDEHYDES; STRUCTURE ACTIVITY RELATIONSHIP; V79/HGPRT ASSAY;

D O I：

10.1016/0027-5107(92)90237-V

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mutagenic activity of 11 sesquiterpenoid unsaturated dialdehydes in the V79/HGPRT assay has been determined, and is compared with previously published data on the mutagenicity of the same compounds towards Ames Salmonella strains. One compound, isovelleral, is a potent mutagen in both assays, while six compounds, which are positive in the Ames Salmonella/microsome assay, show no significant activity in this study. One compound, acetylmerulidial, is negative in the Ames Salmonella/microsome assay but significantly although weakly mutagenic in the V79/HGPRT assay. The remaining three compounds are inactive in both assays. The study is part of a general investigation of quantitative structure-activity relationships for unsaturated dialdehydes, a class of natural occurring compounds known for their potent and numerous biological activities.

引用

页码：315 / 321

页数：7

共 17 条

[1]

ANDERSSON M, 1992, IN PRESS TOXICOL IN

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