CORRELATION BETWEEN CYTOTOXIN PRODUCTION AND SPORULATION IN CLOSTRIDIUM-DIFFICILE

被引：19

作者：

KAMIYA, S ^{[1
]}

OGURA, H ^{[1
]}

MENG, XQ ^{[1
]}

NAKAMURA, S ^{[1
]}

机构：

[1] KANAZAWA UNIV,SCH MED,DEPT BACTERIOL,13-1 TAKARA MACHI,KANAZAWA,ISHIKAWA 920,JAPAN

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 1992年 / 37卷 / 03期

关键词：

D O I：

10.1099/00222615-37-3-206

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Correlation between cytotoxin production and sporulation was demonstrated when a Clostridium difficile culture was inoculated into fresh broth to give an initial count of < 10 vegetative cells/ml with no spores. Under these conditions, cytotoxin was produced and released during sporulation. Addition of a sporulation inhibitor (acridine orange, 30 mg/L), resulted in a marked decrease in both sporulation and cytotoxin production, despite there being no change in the number of vegetative cells in the culture. These results indicate that sporulation might be closely related to cytotoxin production.

引用

页码：206 / 210

页数：5

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