CHARACTERIZATION OF ATRIAL-NATRIURETIC-PEPTIDE RECEPTORS IN HUMAN FETOPLACENTAL VASCULATURE

被引:20
作者
MCQUEEN, J
KINGDOM, JCP
WHITTLE, MJ
CONNELL, JMC
机构
[1] WESTERN INFIRM & ASSOCIATED HOSP,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
[2] UNIV GLASGOW,QUEEN MOTHERS HOSP,DEPT MIDWIFERY,GLASGOW G3 8SH,SCOTLAND
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 264卷 / 03期
关键词
ATRIAL NATRIURETIC PEPTIDE RECEPTOR SUBTYPES; RECEPTOR DISTRIBUTION; PARTICULATE GUANYLATE CYCLASE;
D O I
10.1152/ajpheart.1993.264.3.H798
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Two classes of high-affinity binding sites for atrial natriuretic peptide (ANP) were identified in a microsomal fraction from human placental artery using radioligand binding methods and des[Gln18,Ser19,Gly20,Leu21,Gly22]ANP-(4-23) (C-ANP), a partially ring-deleted analogue of ANP, consistent with the presence of ANP-A and ANP-C receptor subtypes in this tissue [dissociation equilibrium constant (K(d)) 58 pM, maximum binding capacity (B(max)) 14 fmol/mg membrane protein, and K(d) 82 pM, B(max) 28 fmol/mg, respectively]. ANP activated a guanylate cyclase present in a particulate fraction from placental vascular tissue with half-maximal response at 104 pM and a maximal rate of guanosine 3',5'-cyclic monophosphate production of 62 pmol . min-1 . mg protein-1. Human brain natriuretic peptide was 10-fold less effective than ANP in stimulating guanylate cyclase activity, indicating the absence of the ANP-B receptor subtype. C-ANP had no effect on basal or ANP-stimulated enzyme activity. This report demonstrates the presence of functional (guanylate cyclase-coupled) receptors for ANP in the human fetoplacental vasculature, suggesting that ANP may have a role in the regulation of fetoplacental hemodynamics.
引用
收藏
页码:H798 / H804
页数:7
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