INTERLEUKIN 1-INDUCED CANCER CELL ENDOTHELIAL-CELL ADHESION INVITRO AND ITS RELATIONSHIP TO METASTASIS INVIVO - ROLE OF VESSEL WALL 13-HODE SYNTHESIS AND INTEGRIN EXPRESSION

被引:40
作者
BERTOMEU, MC
GALLO, S
LAURI, D
HAAS, TA
ORR, FW
BASTIDA, E
BUCHANAN, MR
机构
[1] HOSP CLIN BARCELONA,DEPT HEMOCOAGULAT,E-08036 BARCELONA,SPAIN
[2] MCMASTER UNIV,DEPT PATHOL,HAMILTON L8N 3Z5,ONTARIO,CANADA
[3] MCMASTER UNIV,DEPT SURG,HAMILTON L8N 3Z5,ONTARIO,CANADA
关键词
ADHESION; CANCER CELL; ENDOTHELIAL CELL; GRGDS PEPTIDE; 13-HODE; INTERLEUKIN; 1-ALPHA; METASTASIS;
D O I
10.1007/BF00121167
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Previously, we have demonstrated that stimulation of endothelial cells (ECs) with interleukin-1alpha (IL-1alpha) enhances the synthesis and expression of the vitronectin receptor (VnR), promotes VnR-dependent adhesion of human A549 adenocarcinoma cells to ECs, and is associated with decreased EC 13-hydroxyoctadecadienoic acid (13-HODE) synthesis in vitro. To determine whether these observations are relevant in vivo, we examined the acute retention and subsequent metastasis of intravenously-injected B16F10 melanoma cells in murine lungs, in relation to vessel wall 13-HODE. In C57BL/6 mice pretreated with IL-1alpha, vessel wall 13-HODE was decreased and B16F10 lung entrapment and metastasis were increased. The latter two events were blocked by pretreating the animals with the GRGDS peptide. These data suggest a relationship between vessel wall 13-HODE synthesis, adhesion molecule expression, and adhesion of B16F10 cells to the endothelium.
引用
收藏
页码:243 / 250
页数:8
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