A DIRECT SYNTHESIS OF A BIFUNCTIONAL CHELATING AGENT FOR RADIOLABELING PROTEINS

被引：21

作者：

BRECHBIEL, MW

MCMURRY, TJ

GANSOW, OA

机构：

[1] Chemistry Section, Radiation Oncology Branch, National Institute of Health, Bethesda

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(00)79202-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthesis of a bifunctional derivative of the ligand NOTA is described. The synthesis offers advantages over current literature methods for making similar molecules by starting with the easily prepared ortho-amide of 1,4,7-triazacyclononane which can be sequentially alkylated to provide a bifunctional NOTA derivative in 9% yield overall. The replacement of preparative HPLC with simple ion-exchange chromatography provides analytically pure ligand suitable for clinical applications.

引用

页码：3691 / 3694

页数：4

共 17 条

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