A FACILE DEHOMOLOGATION OF ALPHA-SUBSTITUTED ALDEHYDES TO THE CORRESPONDING KETONES

被引：11

作者：

HARRIS, CE ^{[1
]}

LEE, LY ^{[1
]}

DORR, H ^{[1
]}

SINGARAM, B ^{[1
]}

机构：

[1] UNIV CALIF SANTA CRUZ,DEPT CHEM & BIOCHEM,SANTA CRUZ,CA 95064

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 17期

关键词：

D O I：

10.1016/0040-4039(95)00467-Q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A systematic study has been completed demonstrating the utility and scope of the potassium dichromate-mediated oxidative cleavage of enamines. Among the methods studied, the biphasic, chromic acid-diethyl ether conditions gave the best results and prevented over-oxidation of the carbonyl produce. This method is general for beta,beta-disubstituted enamines, such as (1E)-1-(4-morpholino)-2-phenyl-2-methyl-1-propene, and gave the corresponding dehomologated ketones in good yield in one hour at 25 degrees C.

引用

页码：2921 / 2924

页数：4

共 11 条

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