ANALYSIS OF GENETIC DIVERSITY AT THE AROM LOCUS IN ISOLATES OF PNEUMOCYSTIS-CARINII

被引：67

作者：

BANERJI, S

LUGLI, EB

MILLER, RF

WAKEFIELD, AE

机构：

[1] JOHN RADCLIFFE HOSP, INST MOLEC MED, DEPT PAEDIAT, MOLEC INFECT DIS GRP, OXFORD OX3 9DU, ENGLAND

[2] UCL HOSP, SCH MED, DEPT MED, LONDON, ENGLAND

[3] NHS TRUST, CAMDEN & ISLINGTON COMMUNITY SERV, LONDON, ENGLAND

来源：

JOURNAL OF EUKARYOTIC MICROBIOLOGY | 1995年 / 42卷 / 06期

关键词：

AMINO ACID SEQUENCE; AROM PROTEIN; DNA SEQUENCE;

D O I：

10.1111/j.1550-7408.1995.tb01614.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The DNA sequences of a portion of the 5-enolpyruvyl shikimate phosphate synthase domain of the arom gene, encoding the pentafunctional AROM protein, were determined from isolates of Pneumocystis carinii from five mammalian host species (rat, human, ferret, rabbit and mouse). High levels of genetic divergence were found among P. carinii derived from different hosts species, 7-22% at the DNA sequence level, and 7-26% at the derived amino acid sequence level. Two separate and distinct sequences were isolated from infected ferret lungs. Low levels of divergence were seen in human-derived organisms.

引用

页码：675 / 679

页数：5

共 31 条

[1] THE CLONING AND CHARACTERIZATION OF THE AROM GENE OF PNEUMOCYSTIS-CARINII [J].