MONOAMINE OXIDASE INHIBITING PROPERTIES OF AB-15 - COMPARISON WITH TRANYLCYPROMINE, NIALAMIDE AND PARGYLINE

AB-15* is a potent inhibitor of MAO both in vitro and in vivo. Single oral application produces long lasting MAO inhibition. AB-15 reverses the action of reserpine and potentiates the 5-HTP induced rise in rectal temperature in mice while having a slight effect on the blood pressure and heart rate responses to tyramine in cats. The in vitro studies on the deamination of different amines, indicate that its inhibiting effect is selective, and dependes markedly on the substrate used. © 1969.