BIOLOGICAL-ACTIVITIES OF PHTHALOCYANINES .11. PHOTOTOXICITY OF SULFONATED ALUMINUM NAPHTHALOCYANINES TOWARDS V-79 CHINESE HAMSTER-CELLS

被引：30

作者：

PAQUETTE, B ^{[1
]}

ALI, H ^{[1
]}

LANGLOIS, R ^{[1
]}

VANLIER, JE ^{[1
]}

机构：

[1] UNIV SHERBROOKE,FAC MED,MRC,RADIAT SCI GRP,SHERBROOKE J1H 5N4,QUEBEC,CANADA

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1990年 / 51卷 / 03期

关键词：

D O I：

10.1111/j.1751-1097.1990.tb01716.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The phototoxicity of sulfonated aluminum naphthalocyanines towards V‐79 Chinese hamster cells is investigated. The disulfonated naphthalocyanine exhibits similar photostability, but better cell penetrating properties than the tetrasulfonated dyes. The capacity of the naphthalocyanines to generate singlet oxygen is comparable to that of the corresponding phthalocyanines. However, in contrast to the phthalocyanine dyes, the sulfonated aluminum naphthalocyanines show very little phototoxicity towards the V‐79 cells, suggesting close association with non‐vital cell constituents or extensive formation of photoinactive adducts and aggregates. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：313 / 317

页数：5

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