SYNTHESIS AND SOME PHARMACOLOGICAL PROPERTIES OF 8-L-METHIONINE-OXYTOCIN

被引：5

作者：

BODANSZKY, M ^{[1
]}

CHANDRAMOULI, N ^{[1
]}

MARTINEZ, J ^{[1
]}

WALTER, R ^{[1
]}

机构：

[1] UNIV ILLINOIS,MED CTR,DEPT PHYSIOL & BIOPHYS,CHICAGO,IL 60680

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 03期

关键词：

D O I：

10.1021/jm00189a010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of 8-L-methionine-oxytocin from iV-[(tert-butyloxy)carbonyl]tocinoic acid and L-prolyl-L-methionylglycinamide is described. Removal of the NH2 protecting group by acidolysis from the partially protected nonapeptide, followed by purification by chromatography, produced the hormone analogue in homogeneous form. It exhibits the pharmacological activities characteristic of the parent hormone, oxytocin. The new analogue, 8-L-methionine-oxytocin, possesses 200 ± 4 units per mg of oxytocic activity determined on the isolated rat uterus, 193 ± 7 units per mg of avian depressor activity, 27 ± 0.8 units per mg of rat pressor activity, and 0.4 ± 0.2 unit per mg of rat antidiuretic activity. © 1979, American Chemical Society. All rights reserved.

引用

页码：270 / 273

页数：4

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