THE EFFECT OF AMYLIN AND CALCITONIN GENE-RELATED PEPTIDE ON INSULIN-STIMULATED GLUCOSE-TRANSPORT IN THE DIAPHRAGM

被引：38

作者：

HOTHERSALL, JS ^{[1
]}

MUIRHEAD, RP ^{[1
]}

WIMALAWANSA, S ^{[1
]}

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT MED,BIOCHEM ENDOCRINOL UNIT,LONDON W12 0NN,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 169卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)90352-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The two peptides calcitonin gene related peptide (CGRP) and amylin at 1uM levels in an isolated rat diaphragm preparation inhibited insulin stimulated 2-deoxy[3H]glucose transport by 30 and 60 percent, respectively; this was the case at maximal (1mU) and sub-maximal (0.5mU) insulin concentrations. No effect was measured on the basal level of 2-deoxy[3H]glucose transport. © 1990.

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页码：451 / 454

页数：4

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