VERAPAMIL-INDUCED INHIBITION OF THEOPHYLLINE ELIMINATION IN HEALTHY HUMANS

被引：16

作者：

NIELSENKUDSK, JE ^{[1
]}

BUHL, JS ^{[1
]}

JOHANNESSEN, AC ^{[1
]}

机构：

[1] RANDERS GEN HOSP,DEPT CLIN CHEM,DK-8900 RANDERS,DENMARK

来源：

PHARMACOLOGY & TOXICOLOGY | 1990年 / 66卷 / 02期

关键词：

D O I：

10.1111/j.1600-0773.1990.tb00713.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The interaction between theophylline and verapamil was investigated in 7 healthy volunteers. Oral administration of verapamil in a dose of 120 mg t.i.d. for 7 days caused a significant inhibition of the elimination of theophylline (5 mg/kg intravenously). Theophylline clearance was reduced from 45.2 to 36.1 ml/hr/kg (20.1%; P<0.005). The apparent steady‐state volume of distribution of the drug was not influenced. The terminal half‐life of theophylline was increased from 6.80 to 8.23 hr (21.0%; P<0.001). Increased steady‐state plasma theophylline concentrations may thus be expected when verapamil is added to a drug regimen which includes theophylline. 1990 Nordic Pharmacological Society

引用

页码：101 / 103

页数：3

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