EFFECT OF DIMETHYLSULFOXIDE ON CYSTEAMINE-INDUCED DUODENAL ULCERATION IN RATS

被引：5

作者：

ALI, BH

机构：

[1] Department of Pharmacology, Faculty of Medicine, Al-Arab Medical University, Benghazi

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1990年 / 17卷 / 06期

关键词：

cysteamine; dimethylsulphoxide; duodenal ulceration;

D O I：

10.1111/j.1440-1681.1990.tb01345.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Rats were pretreated with dimethylsulphoxide (DMSO) at concentrations of 2, 4 and 6% v/v in the drinking water for 7 days, then injected with a single subcutaneous dose of cysteamine (28 mg/100 g bodyweight) to induce duodenal ulceration. 2. DMSO reduced, in a dose‐dependent manner, the incidence and extent of the ulceration. 3. Mucus duodenal content was not significantly affected by either DMSO or cysteamine treatments. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：463 / 466

页数：4

共 15 条

[1]

ALI BH, 1989, IN PRESS PHARMACOLOG

[2] EVIDENCE FOR HYDROXYL FREE-RADICAL FORMATION DURING PARAQUAT BUT NOT FOR NIFURTIMOX LIVER MICROSOMAL BIOTRANSFORMATION - A DIMETHYLSULFOXIDE SCAVENGING STUDY [J].