COMPLICATED MIGRAINE STUDIED BY PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY

被引：75

作者：

BARBIROLI, B

MONTAGNA, P

CORTELLI, P

MARTINELLI, P

SACQUEGNA, T

ZANIOL, P

LUGARESI, E

机构：

[1] Istituto di Clinica Neurologica, Università di Bologna, 40123 Bologna, Via U. Foscolo

[2] Istituto di Radiologia, Università di Modena, 4110 Modena, Via del Pozzo

来源：

CEPHALALGIA | 1990年 / 10卷 / 05期

关键词：

Brain bioenergetics; energy metabolism; exercising human skeletal muscle; impaired human brain energy metabolism;

D O I：

10.1046/j.1468-2982.1990.1005263.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The brain and skeletal muscle of eight adult patients with migraine with prolonged auras or migraine strokes leaving a permanent hemianopic defect were studied by phosphorus magnetic resonance spectroscopy. Biochemical assays performed on muscle biopsy and platelets had revealed abnormal mitochondrial enzyme activities. Brain magnetic resonance spectroscopy showed an abnormally low phosphocreatine to inorganic phosphate ratio in all patients, apparently due to decreased phosphocreatine and increased inorganic phosphate contents. Muscle phosphorus magnetic resonance spectroscopy showed low recovery from exercise in seven patients. Three patients had an increased phosphocreatine/inorganic phosphate ratio at rest, and the exercise transfer characteristics were abnormal in four patients for relatively low levels of exercise. The mitochondrial metabolic defects present in platelets and muscle of complicated migraine patients are therefore also expressed in the brain. © 1990, International Headache Society. All rights reserved.

引用

页码：263 / 272

页数：10

共 35 条

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