12 HOURS BRONCHODILATING EFFECT OF INHALED FORMOTEROL IN CHILDREN WITH ASTHMA - A DOUBLE-BLIND CROSS-OVER STUDY VERSUS SALBUTAMOL

被引：32

作者：

GRAFFLONNEVIG, V ^{[1
]}

BROWALDH, L ^{[1
]}

机构：

[1] KAROLINSKA INST,SACHS CHILDRENS HOSP,S-10401 STOCKHOLM 60,SWEDEN

来源：

CLINICAL AND EXPERIMENTAL ALLERGY | 1990年 / 20卷 / 04期

关键词：

D O I：

10.1111/j.1365-2222.1990.tb02805.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Thirteen children, mean age 10·9 yr, with perennial asthma, were studied with respect to the duration of the bronchodilating effect of formoterol, a new long‐acting β2 agonist for inhalation. The duration of action of formoterol metered dose aerosol (12 μg) was compared with salbutamol metered dose aerosol (200 μg) in a double‐blind cross‐over study. Formoterol was found to have significantly better bronchodilating effect 8 hr (P < 0·01) and 12 hr (P < 0·05) after inhalation of the drug. Formoterol (24 μg) was given single‐blindly on the third trial day and showed a tendency towards a better bronchodilating effect (n.s.) than formoterol (12 μg.). There was no difference between the treatments with regard to adverse reactions such as tremor, palpitations, raised heart rate or anxiety. Formoterol proved to be superior to salbutamol as a long‐acting bronchodilator in children with bronchial asthma. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：429 / 432

页数：4

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