HISTOCHEMICAL-LOCALIZATION OF SUPEROXIDE PRODUCTION IN EXPERIMENTAL AUTOIMMUNE UVEITIS

被引：39

作者：

GRITZ, DC

MONTES, C

ATALLA, LR

WU, GS

SEVANIAN, A

RAO, NA

机构：

[1] UNIV SO CALIF, SCH MED, DOHENY EYE INST, 1355 SAN PABLO ST, LOS ANGELES, CA 90033 USA

[2] UNIV SO CALIF, SCH MED, DEPT OPHTHALMOL, LOS ANGELES, CA 90033 USA

[3] UNIV SO CALIF, SCH MED, INST TOXICOL, LOS ANGELES, CA 90033 USA

[4] UNIV SO CALIF, SCH MED, DEPT PATHOL, LOS ANGELES, CA 90033 USA

来源：

CURRENT EYE RESEARCH | 1991年 / 10卷 / 10期

关键词：

D O I：

10.3109/02713689109020328

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Although the presence and role of oxygen reactive species in uveal inflammation is the subject of intense investigation, there is little direct evidence that oxygen metabolites are present at the site of inflammation. We used the nitroblue tetrazolium test for superoxide to determine production of this oxygen reactive species in experimental autoimmune uveitis (EAU). The choroidal tissues of animals with this disease contained intracellular, blue-staining granules. Most of the positive staining cells appeared to be polymorphonuclear leukocytes. This localization of superoxide in EAU is further evidence of the generation of oxygen reactive species in uveal inflammation.

引用

页码：927 / 931

页数：5

共 13 条

[1] IMMUNOHISTOCHEMICAL LOCALIZATION OF CATALASE IN OCULAR TISSUE [J].