THE ANTIPARKINSON EFFICACY OF DEPRENYL DERIVES FROM TRANSIENT IMPROVEMENT THAT IS LIKELY TO BE SYMPTOMATIC

被引:95
作者
SCHULZER, M
MAK, E
CALNE, DB
机构
[1] Neurodegenerative Disorders Centre, Department of Medicine, University Hospital, Vancouver, British Columbia
关键词
D O I
10.1002/ana.410320614
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We undertook an analysis of the hazard functions derived from results published by the Parkinson Study Group following their investigation of deprenyl. Our findings indicate that the action of deprenyl is transient rather than sustained. We also infer that this effect may be mediated through alleviation of symptoms rather than by neuroprotection.
引用
收藏
页码:795 / 798
页数:4
相关论文
共 19 条
[1]  
BARLOW RE, 1975, STATISTICAL THEORY R, P52
[2]   DEPRENYL EFFECTS ON LEVODOPA PHARMACODYNAMICS, MOOD, AND FREE-RADICAL SCAVENGING [J].
BARONTI, F ;
DAVIS, TL ;
BOLDRY, RC ;
MOURADIAN, MM ;
CHASE, TN .
NEUROLOGY, 1992, 42 (03) :541-544
[3]   POSITRON EMISSION TOMOGRAPHY SUGGESTS THAT THE RATE OF PROGRESSION OF IDIOPATHIC PARKINSONISM IS SLOW [J].
BHATT, MH ;
SNOW, BJ ;
MARTIN, WRW ;
PATE, BD ;
CALNE, DB .
ANNALS OF NEUROLOGY, 1991, 29 (06) :673-677
[4]  
COX DR, 1984, ANAL SURVIVAL DATA, P91
[5]  
CROWDER MJ, 1991, STATISTICAL ANAL REL, P12
[6]   ESTIMATING SURVIVAL FUNCTIONS FROM LIFE TABLE [J].
GEHAN, EA .
JOURNAL OF CHRONIC DISEASES, 1969, 21 (9-10) :629-+
[7]  
GREVILLE TNE, 1969, THEORY APPLICATIONS
[8]   NONPARAMETRIC-ESTIMATION FROM INCOMPLETE OBSERVATIONS [J].
KAPLAN, EL ;
MEIER, P .
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1958, 53 (282) :457-481
[9]   ESTIMATION OF MORTALITY INTENSITIES IN ANIMAL EXPERIMENTS [J].
KIMBALL, AW .
BIOMETRICS, 1960, 16 (04) :505-521
[10]  
LAWLESS JF, 1982, STATISTICAL MODELS M, P11