MYALGIA AND ELEVATED CREATINE-KINASE ACTIVITY ASSOCIATED WITH SUBCUTANEOUS INJECTIONS OF DILUENT

被引：12

作者：

BACH, MA

BLUM, DM

ROSE, SR

CHARNAS, LR

机构：

[1] NICHHD, HUMAN GENET BRANCH, BETHESDA, MD 20892 USA

[2] NIH, WARREN GRANT MAGNUSON CLIN CTR, DEPT NURSING, BETHESDA, MD 20892 USA

[3] UNIV NEW MEXICO, DEPT PEDIAT, ALBUQUERQUE, NM 87131 USA

来源：

JOURNAL OF PEDIATRICS | 1992年 / 121卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0022-3476(05)81165-5

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A 16-year-old boy with short stature and mild primary hypothyroidism received subcutaneous injections of either recombinant human growth hormone or placebo in diluent that contained glycerol and m-cresol as a preservative. While he was receiving the study drug, myalgia developed and serum creatine kinase values were elevated. Both resolved when injections were stopped and recurred when injections of diluent alone were given. The myalgia and elevated creatine kinase activity were apparently caused by a component of the diluent.

引用

页码：650 / 651

页数：2

共 5 条

[1] BENIGN ACUTE CHILDHOOD MYOSITIS [J].