THE HYDROPHILIC SPIN TRAP, 5,5-DIMETHYL-1-PYRROLINE-1-OXIDE, DOES NOT PROTECT THE RAT-HEART FROM REPERFUSION INJURY

被引：10

作者：

BRADAMANTE, S ^{[1
]}

JOTTI, A ^{[1
]}

PARACCHINI, L ^{[1
]}

MORTI, E ^{[1
]}

机构：

[1] UNIV MILAN,IST FARMACOL APPL,I-20133 MILAN,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 234卷 / 01期

关键词：

ISCHEMIA REPERFUSION; HEART; FREE RADICALS; SPIN TRAPS; DMPO (5,5-DIMETHYL-1-PYRROLINE-1-OXIDE);

D O I：

10.1016/0014-2999(93)90713-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The role and site of free radical generation in myocardial ischemia/reperfusion injury were investigated using the hydrophilic spin trapping agent, 5,5-dimethyl-1-pyrroline-1-oxide (DMPO). DMPO (40 mM) proved ineffective in preserving the contractile performance and energy metabolism of Langendorff-perfused rat hearts following ischemia and reperfusion. This result, which is in contrast with the cardioprotection observed with hydrophobic spin traps, suggests that free radicals are generated intracellularly under these conditions.

引用

收藏

页码：113 / 116

页数：4

相关论文

共 17 条

[1] DEMONSTRATION OF FREE-RADICAL GENERATION IN STUNNED MYOCARDIUM OF INTACT DOGS WITH THE USE OF THE SPIN TRAP ALPHA-PHENYL N-TERT-BUTYL NITRONE [J].

BOLLI, R ;

PATEL, BS ;

JEROUDI, MO ;

LAI, EK ;

MCCAY, PB .

JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (02) :476-485

[2] MARKED REDUCTION OF FREE-RADICAL GENERATION AND CONTRACTILE DYSFUNCTION BY ANTIOXIDANT THERAPY BEGUN AT THE TIME OF REPERFUSION - EVIDENCE THAT MYOCARDIAL STUNNING IS A MANIFESTATION OF REPERFUSION INJURY [J].

BOLLI, R ;

JEROUDI, MO ;

PATEL, BS ;

ARUOMA, OI ;

HALLIWELL, B ;

LAI, EK ;

MCCAY, PB .

CIRCULATION RESEARCH, 1989, 65 (03) :607-622

[3] DIRECT EVIDENCE THAT OXYGEN-DERIVED FREE-RADICALS CONTRIBUTE TO POSTISCHEMIC MYOCARDIAL DYSFUNCTION IN THE INTACT DOG [J].

BOLLI, R ;

JEROUDI, MO ;

PATEL, BS ;

DUBOSE, CM ;

LAI, EK ;

ROBERTS, R ;

MCCAY, PB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (12) :4695-4699

[4] PROTECTIVE ACTIVITY OF THE SPIN TRAP TERT-BUTYL-ALPHA-PHENYL NITRONE (PBN) IN REPERFUSED RAT-HEART [J].

BRADAMANTE, S ;

MONTI, E ;

PARACCHINI, L ;

LAZZARINI, E ;

PICCININI, F .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1992, 24 (04) :375-386

[5] SUBCELLULAR-DISTRIBUTION OF 2 SPIN TRAPPING AGENTS IN RAT-HEART - POSSIBLE EXPLANATION FOR THEIR DIFFERENT PROTECTIVE EFFECTS AGAINST DOXORUBICIN-INDUCED CARDIOTOXICITY [J].

COVA, D ;

DEANGELIS, L ;

MONTI, E ;

PICCININI, F .

FREE RADICAL RESEARCH COMMUNICATIONS, 1992, 15 (06) :353-360

[6] SPIN TRAPPING OF LIPID-DERIVED RADICALS IN LIPOSOMES [J].

FEIX, JB ;

KALYANARAMAN, B .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 992 (02) :230-235

[7] SPIN TRAPPING - KINETICS OF THE REACTION OF SUPEROXIDE AND HYDROXYL RADICALS WITH NITRONES [J].

FINKELSTEIN, E ;

ROSEN, GM ;

RAUCKMAN, EJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (15) :4994-4999

[8]

FLAHERTY JT, 1982, CIRCULATION, V65, P565

[9]

JACOBUS WE, 1973, J BIOL CHEM, V248, P4803

[10]

KLINER RA, 1983, CIRCULATION S1, V66, P1