RESPONSE OF THE WHOLE BLADDER-URETHRA MODEL (RABBIT) TO AUTONOMIC DRUGS

被引：5

作者：

CHUN, AL ^{[1
]}

WEIN, AJ ^{[1
]}

GILL, HS ^{[1
]}

LEVIN, RM ^{[1
]}

机构：

[1] UNIV PENN,PRESBYTERIAN MED CTR,DIV UROL,3010 RAVDIN CTYD BLDG,3400 SPRUCE ST,PHILADELPHIA,PA 19104

来源：

NEUROUROLOGY AND URODYNAMICS | 1990年 / 9卷 / 02期

关键词：

alpha‐adrenergic; atropine; urethra; urinary bladder;

D O I：

10.1002/nau.1930090209

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

To investigate the function of the bladder‐urethra as a continuous unit we set up an in vitro whole bladder‐urethra model (rabbit). We were able to measure the intravesical pressure at which saline infused into the bladder emptied via the urethra (“opening pressure”). Methoxamine added to the bath caused a significant increase in opening pressure, whereas phentolamine caused a significant decrease in opening pressure compared to controls. Atropine had no effect on opening pressure in the absence or presence of methoxamine. Thus, it appears that the in vitro bladder‐urethra unit has intrinsic alpha‐adrenergic tone that is of sufficient force to maintain an intravesical pressure of 7.0 cm H2O, and that this tone is not influenced by antagonism with the anticholinergic agent atropine. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：165 / 169

页数：5

共 6 条

[1]

Larsson B, Andersson K-E, Mattiasson A, Influence of antimuscarinics on alpha‐adrenoceptors in the female rabbit urethra, Acta Physiol Scand, 120, (1984)

[2]

Levin RM, Wein AJ, Response of in‐vitro bladder (rabbit) preparation to autonomic agonists, J Urol, 128, (1982)

[3]

Maggi CA, Santicioli P, Meli A, Pharmacological evidence for the existence of two components of the twitch response to field stimulation of detrusor strips from the rat urinary bladder, J Auton Pharmacol, 5, (1985)

[4]

Mattiasson A, Andersson K-E, Sjogren C, Adrenoceptors and cholinoceptors controlling noradrenaline release from adrenergic nerves in the urethra of the rabbit and man, J Urol, 131, (1984)

[5]

Nergardh A, Boreus LO, The functional role of cholinergic receptors in the outlet region of the urinary bladder: an in vitro study in the cat, Acta Pharmacol Toxicol, 32, (1973)

[6]

Wein AJ, Barrett DM, Voiding Function and Dysfunction: A Logical and Practical Approach, (1988)

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