ANTIOXIDANT CHARACTERISTICS OF SOME POTENTIAL ANTICATARACT AGENTS - STUDIES OF ASPIRIN, PARACETAMOL, AND BENDAZAC PROVIDE SUPPORT FOR AN OXIDATIVE COMPONENT OF CATARACT

被引：49

作者：

WOOLLARD, ACS ^{[1
]}

WOLFF, SP ^{[1
]}

BASCAL, ZA ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,DEPT CLIN PHARMACOL,TOXICOL LAB,5 UNIV ST,LONDON WC1E 6JJ,ENGLAND

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 9卷 / 04期

关键词：

Antioxidant; Cataract; Free radicals; Oxidative stress;

D O I：

10.1016/0891-5849(90)90004-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is conceivable that drugs with anticataract potential possess antioxidant activity. Using defined chelating agents and reducing agents in a number of assays for antioxidant activity, we have deomstrated that paracetamol, aspirin, bendazac, and its metabolite 5-hydroxybendazac possess substantial reducing and/or metal-chelating activity. We found that paracetamol and 5-hydroxybendazac reduced the dipehenylpicrylhydrazyl free radical; inhibited butyl peroxide-induced erythrocyte lysis as well as the haematin-catalyzed oxidative couling of 4-aminoantipyrine and phenol by butyl peroxide. Furthermore, paracetamol, bendazac, and aspirin competed with 3-(2-pyridyl)-5,6-Diphenyl-1,2,4-triazine-4′,4′'-disulphonic acid (ferrozine) for ferrous ion. © 1990.

引用

页码：299 / 305

页数：7

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