WEST NILE VIRIONS ALIGNED ALONG MYELIN LAMELLAE IN ORGANOTYPIC SPINAL-CORD CULTURES

被引：10

作者：

SHAHAR, A ^{[1
]}

LUSTIG, S ^{[1
]}

AKOV, Y ^{[1
]}

DAVID, Y ^{[1
]}

SCHNEIDER, P ^{[1
]}

FRIEDMANN, A ^{[1
]}

LEVIN, R ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM, DEPT GENET, JERUSALEM, ISRAEL

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1990年 / 26卷 / 04期

关键词：

interperiod lines; myelin sheath; West Nile virus;

D O I：

10.1002/jnr.490260413

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Organtypic spinal cord cultures infected with West Nile Virus (WNV) exhibited a remarkable arrangement of virions among lamellae of the myelin sheath. Virions were first observed in neurons and only at day 4 after infection appeared within the myelin lamellae. Virions were observed only in the central myelin, aligned along the interperiod lines and therefor attached to the outer side of the oligodendrocyte membrane. In spite of this peculiar location of the virions, their presence was not associated with severe damage to the axon or to the myelin sheath. The causes of the formation of this viral pattern, its morphological features, and the role which it might have in viral infection in vivo are considered. Copyright © 1990 Wiley‐Liss, Inc.

引用

页码：495 / 500

页数：6

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