ADH AND ALDH GENOTYPE PROFILES IN CAUCASIANS WITH ALCOHOL-RELATED PROBLEMS AND CONTROLS

被引：51

作者：

GILDER, FJ

HODGKINSON, S

MURRAY, RM

机构：

[1] INST PSYCHIAT,DEPT PSYCHOL MED,PSYCHIAT GENET SECT,LONDON SE5 8AF,ENGLAND

[2] UNIV LONDON KINGS COLL HOSP,LONDON SE5 8RX,ENGLAND

来源：

ADDICTION | 1993年 / 88卷 / 03期

关键词：

D O I：

10.1111/j.1360-0443.1993.tb00825.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Eighty-two Caucasian patients receiving treatment for alcohol-related problems and eighty four controls were DNA typed for variants in the alcohol dehydrogenase (ADH-2 and ADH-3) and mitochondrial aldehyde dehydrogenase (ALDH-2) gene loci. No association was observed between individual, or combined gene frequencies and the presence of alcohol-related problems.

引用

页码：383 / 388

页数：6

共 23 条

[1] ALLELIC ASSOCIATION OF HUMAN DOPAMINE-D2 RECEPTOR GENE IN ALCOHOLISM [J].

BLUM, K ;

NOBLE, EP ;

SHERIDAN, PJ ;

MONTGOMERY, A ;

RITCHIE, T ;

JAGADEESWARAN, P ;

NOGAMI, H ;

BRIGGS, AH ;

COHN, JB .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 263 (15) :2055-2060

[2]

BOHMAN M, 1981, ARCH GEN PSYCHIAT, V38, P965

[3]

Bosron W F, 1981, Semin Liver Dis, V1, P179, DOI 10.1055/s-2008-1041746

[4] HUMAN-LIVER ALCOHOL-DEHYDROGENASE - ADHINDIANAPOLIS RESULTS FROM GENETIC-POLYMORPHISM AT THE ADH2 GENE LOCUS [J].

BOSRON, WF ;

MAGNES, LJ ;

LI, TK .

BIOCHEMICAL GENETICS, 1983, 21 (7-8) :735-744

[5] FAMILIAL INCIDENCE OF ALCOHOLISM - REVIEW [J].

COTTON, NS .

JOURNAL OF STUDIES ON ALCOHOL, 1979, 40 (01) :89-116

[6]

DUESTER G, 1984, P NATIONAL ACADEMY S, V84, P4055

[7] ALCOHOL AND ALDEHYDE DEHYDROGENASE [J].

EHRIG, T ;

BOSRON, WF ;

LI, TK .

ALCOHOL AND ALCOHOLISM, 1990, 25 (2-3) :105-116

[8] GENOTYPING OF HUMAN CLASS-I ALCOHOL-DEHYDROGENASE - ANALYSIS OF ENZYMATICALLY AMPLIFIED DNA WITH ALLELE-SPECIFIC OLIGONUCLEOTIDES [J].

GENNARI, K ;

WERMUTH, B ;

MUELLENER, D ;

EHRIG, T ;

VONWARTBURG, JP .

FEBS LETTERS, 1988, 228 (02) :305-309

[9]

GOEDDE HW, 1983, AM J HUM GENET, V35, P769

[10]

GOEDDE HW, 1979, HUM GENET, V51, P331

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