POROUS CELLULOSE MATRICES - A NOVEL EXCIPIENT FOR THE FORMULATION OF SOLID DOSAGE FORMS

被引：12

作者：

DAVIDSON, R ^{[1
]}

NYQVIST, H ^{[1
]}

RAGNARSSON, G ^{[1
]}

机构：

[1] KABI PHARMACIA THERAPEUT AB,S-11287 STOCKHOLM,SWEDEN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 100卷 / 1-3期

关键词：

MULTIPLE UNIT SYSTEM; DRUG CARRIER; CELLULOSE; MICROCRYSTALLINE CELLULOSE; POROUS BEAD; SPHERICAL MATRIX;

D O I：

10.1016/0378-5173(93)90074-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel pharmaceutical aid prepared from a specially processed cellulose is presented. The material, which consists of highly porous spherical cellulose beads, is regarded as having a considerable field of application in dry pharmaceutical formulation. Primarily, the material may act as a multiple unit carrier and release controlling system as well as an additive for the compression of multiple unit preparations in the form of compressed and disintegrating tablets. This paper describes formulation possibilities, and presents some of the essential characteristics and preliminary results on some applications.

引用

页码：49 / 54

页数：6