THE EVALUATION OF A 3-DIMENSIONAL SHAPE FACTOR FOR THE QUANTITATIVE ASSESSMENT OF THE SPHERICITY AND SURFACE-ROUGHNESS OF PELLETS

被引：44

作者：

PODCZECK, F

NEWTON, JM

机构：

[1] Department of Pharmaceutics, The School of Pharmacy, University of London, London, WC1N 1AX

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 124卷 / 02期

关键词：

IMAGE ANALYSIS; PARTICLE SHAPE; PELLET; SPHERICITY; SURFACE ROUGHNESS;

D O I：

10.1016/0378-5173(95)00096-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A three-dimensional shape factor for the characterisation of the quality of pellets has been developed based on image analysis. The shape factor includes the separate assessment of deviations from the spherical shape and the presence of surface roughness. These two components can be viewed and compared with the overall three-dimensional shape factor e(c3), which connects the two features. The shape factor e(c3) has been applied to three sets of pellets prepared by extrusion/spheronisation, and a comparison with the Heywood shape factors has been undertaken. The results demonstrate the ability of e(c3) to differentiate various batches of pellets based on a defined mathematics, whereas the Heywood shape factors require certain assumptions about the particle outline to be applicable.

引用

页码：253 / 259

页数：7

共 18 条

[1] THE SHAPE OF ROCK PARTICLES, A CRITICAL-REVIEW [J].