WORLD DISTRIBUTION OF FACTOR-V LEIDEN

被引：1084

作者：

REES, DC

COX, M

CLEGG, JB

机构：

[1] MRC Molecular Haematology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, 0X3 9DU, Headington

来源：

LANCET | 1995年 / 346卷 / 8983期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0140-6736(95)91803-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have analysed 3380 chromosomes (1690 unrelated individuals) from twenty-four populations for the presence of factor V Leiden, an important risk factor in venous thromboembolism, The allele frequency in 618 Europeans was 4.4%, with the highest prevalence among Greeks (7%). It was 0.6% in Asia Minor. Factor V Leiden was not found in any of 1600 chromosomes from Africa, Southeast Asia, Australasia, and the Americas. This distribution may partly explain the rarity of thromboembolic disease in these populations, The high prevalence in Europeans suggests that screening for this mutation should be considered in some circumstances.

引用

页码：1133 / 1134

页数：2

共 10 条

[1] MUTATION IN BLOOD-COAGULATION FACTOR-V ASSOCIATED WITH RESISTANCE TO ACTIVATED PROTEIN-C [J].

BERTINA, RM ;

KOELEMAN, BPC ;

KOSTER, T ;

ROSENDAAL, FR ;

DIRVEN, RJ ;

DERONDE, H ;

VANDERVELDEN, PA ;

REITSMA, PH .

NATURE, 1994, 369 (6475) :64-67

[2] VARICOSE VEINS, DEEP VEIN-THROMBOSIS, AND HEMORRHOIDS - EPIDEMIOLOGY AND SUGGESTED ETIOLOGY [J].

BURKITT, DP .

BMJ-BRITISH MEDICAL JOURNAL, 1972, 2 (5813) :556-+

[3] THE MOLECULAR-GENETICS OF FAMILIAL VENOUS THROMBOSIS [J].

COOPER, DN .

BAILLIERES CLINICAL HAEMATOLOGY, 1994, 7 (03) :637-674

[4] FAMILIAL THROMBOPHILIA DUE TO A PREVIOUSLY UNRECOGNIZED MECHANISM CHARACTERIZED BY POOR ANTICOAGULANT RESPONSE TO ACTIVATED PROTEIN-C - PREDICTION OF A COFACTOR TO ACTIVATED PROTEIN-C [J].

DAHLBACK, B ;

CARLSSON, M ;

SVENSSON, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (03) :1004-1008

[5]

FLINT J, 1993, HUM GENET, V91, P91

[6]

KOELEMAN BPC, 1994, BLOOD, V84, P1031

[7] VENOUS THROMBOSIS DUE TO POOR ANTICOAGULANT RESPONSE TO ACTIVATED PROTEIN-C - LEIDEN THROMBOPHILIA STUDY [J].

KOSTER, T ;

ROSENDAAL, FR ;

DERONDE, H ;

BRIET, E ;

VANDENBROUCKE, JP ;

BERTINA, RM .

LANCET, 1993, 342 (8886-7) :1503-1506

[8] EPIDEMIOLOGY OF COAGULATION DISORDERS [J].

NATHWANI, AC ;

TUDDENHAM, EGD .

BAILLIERES CLINICAL HAEMATOLOGY, 1992, 5 (02) :383-439

[9] MUTATION IN THE GENE CODING FOR COAGULATION-FACTOR-V AND THE RISK OF MYOCARDIAL-INFARCTION, STROKE, AND VENOUS THROMBOSIS IN APPARENTLY HEALTHY-MEN [J].

RIDKER, PM ;

HENNEKENS, CH ;

LINDPAINTER, K ;

STAMPFER, MJ ;

EISENBERG, PR ;

MILETICH, JP .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (14) :912-917

[10] HIGH-RISK OF THROMBOSIS IN PATIENTS HOMOZYGOUS FOR FACTOR-V LEIDEN (ACTIVATED PROTEIN-C RESISTANCE) [J].

ROSENDAAL, FR ;

KOSTER, T ;

VANDENBROUCKE, JP ;

REITSMA, PH .

BLOOD, 1995, 85 (06) :1504-1508

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