MASS-SPECTROMETRIC DETECTION OF CARCINOGEN ADDUCTS

被引:46
作者
FARMER, PB
SWEETMAN, GMA
机构
[1] Mrc Toxicology Unit, University of Leicester, Leicester, LE1 9HN, Hodgkin Building, P.O. Box 138, Lancaster Road
来源
JOURNAL OF MASS SPECTROMETRY | 1995年 / 30卷 / 10期
关键词
D O I
10.1002/jms.1190301002
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Genotoxic carcinogens interact with nucleic acids and proteins to yield covalently bound products (adducts), the quantitative determination of which has been proposed as a biomonitor of human exposure to carcinogens. Mass spectrometry is playing a leading role both in the structural characterisation and in the quantitative determination of these carcinogen adducts. In particular electrospray ionisation and matrix assisted laser desorption ionisation are being increasingly used in nucleotide and protein adduct detection and in sequencing of carcinogen-modified oligonucleotides and peptides. Quantitative determination of carcinogen-modified nucleic acid bases and protein amino acids is generally carried out by GC/MS or GC/MS/MS, the highest sensitivity being achieved using negative ion chemical ionisation. These techniques are now being applied to samples from humans exposed to carcinogens from environmental, medicinal and occupational sources.
引用
收藏
页码:1369 / 1379
页数:11
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